Skip to main content

Event Details

  • Monday, February 25, 2019
  • 11:15 - 11:45

Recent Advances in Electrochemical Biosensors Based on Molecularly Imprinted Polymers and Nanomaterials

Molecularly imprinted polymers (MIPs) are considered as stable polymers with molecular recognition abilities, provided by the presence of a template during their synthesis. They are generally used to mimic the natural biological receptors used such as antibodies and enzymes. MIPs offered various advantages such as robust, with high stability, required low-cost preparation, and great specific recognition ability with a good sensitivity towards the targeted analyte. Molecularly imprinted polymers based electrochemical sensors were applied for the detection of various kinds of analytes from small molecule such as metals ions and amino acids to much larger proteins, bacteriophage and microbial cells. Owing to their high conductivity, magnetic nanoparticles (MNPs), graphene oxides, multi/single-walled carbon nanotubes (MWCNTs/SWCNTs), and carbon dots are introduced within the MIP films leading to a great sensitivity enhancement of the MIP biomimetic sensors. Magnetite nanoparticles (Fe 3 O 4 NPs) were widely used due to their separation and pre-concentration properties in combination with the molecularly imprinted polymer, which can capture and bind selectively the target analyte. Magnetic molecularly imprinted polymer modified screen printed carbon electrode (Fe3O 4 -MIP/SPCE) combined with various kind of nanomaterials are usually characterized electrochemically using cyclic voltammetry and electrochemical impedance spectroscopy in presence of redox probe such as solution of ferri-ferrocyanide. In this conference, I will present a general overview on the recent advances related to the combination of MIPs and nanomaterials for electrochemical sensing. I will discuss the experimental results obtained with biomimetic sensors based on molecularly imprinting polymers for the detection of emerging pollutants including drugs such as sulphonamides and 17-ß estradiol and endocrine disruptors such as bisphenol A at trace level in various environmental matrices. Furthermore, development of label-free electrochemical sensor based on spore-imprinted polymer for Bacillus cereus spore detection and the effect of ultrasonication on reducing time of MIPs synthesis will be discussed.