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Event Details

  • Monday, February 25, 2019
  • 10:45 - 11:15

Lab on CMOS Biosensors for Minimally Invasive Health Monitoring

Lab-on-a-chip (LOC) systems are miniaturized devices that integrate several laboratory functions onto a single “chip”. The “chips” in LOC systems are usually passive substrates, so most LOC systems are typically used in conjunction with benchtop equipment for sensing and control. By integrating active electronics into traditional passive LOC systems, a new class of highly integrated multiphysics lab-on-CMOS (LOCMOS) systems has emerged that places instrumentation in intimate contact with sensing and actuation capabilities. The integration of sensing with signal processing, detection, and actuation reduces the need for external instrumentation, leading to overall systems with significantly smaller size and also the potential for completely novel measurements that cannot be performed using traditional approaches. Such devices have the potential to introduce significant and disruptive changes in healthcare diagnosis and delivery in the near future. This talk will provide an overview of emerging LoCMOS biosensors that have been designed to monitor diagnostic biomedical signals, including the detection of neuromuscular activation, biochemical analytes, and optical assays, and also progress that has been reported in the integration of these sensors into biomedical devices. The integration of diagnostic sensors into biomedical devices poses a number of distinct and vexing challenges, including packaging, surface fouling, sterilization, communication, and system power.  Finally, we’ll describe two diagnostic biomedical applications for LoCMOS: 1) a cancer box that aims to extend LoCMOS into an implantable diagnostic device to isolate and contain cancer cells for the purpose of measuring their viability and in vivo response to chemotherapeutic agents; and 2) an ingestible pill that measures biochemical signals in the digestive tract.