Skip to main content

Event Details

  • Tuesday, February 26, 2019
  • 09:15 - 10:00

Nanosystems for Food, Drug and Biomedical Applications

Nanotechnology allows for the unique design and functionalization of materials and devices at the nanometer scale for a variety of applications. Our laboratory has fabricated nanosystems for drug screening, in vitro toxicology, sample preparation, diagnostic, and food pathogen detection. The miniaturized devices allow for the rapid and automated processing of drug candidates, clinical and food samples in tiny volumes, greatly facilitating drug testing, genotyping assays, infectious disease detection, cancer diagnosis, point-of-care monitoring, and food testing. For example, we have designed plasmonic nanocrystals for single nucleotide polymorphism (SNP) genotyping. The platform involves polymerase chain reaction (PCR) for target sequence amplification and colorimetric detection with nanoprobes for pharmacogenomics applications. We have also established polymer-based lab-on-a-cartridge for automated sample preparation and PCR detection. The integrated all-in-one system, termed MicroKit, allows for the rapid and accurate typing and subtyping of influenza and other viral infections within 2 hours. We have further developed sophisticated lab-on-a-chip system that enables us to achieve multiplexed detection of drug-resistant bacteria and food pathogens. We have created the silicon-based Microsieve system for the rapid and selective isolation of circulating tumor cells (CTCs) from peripheral blood. This non-invasive, near real-time, inexpensive liquid biopsy approach allows for the enumeration and biomarker analysis of CTCs for cancer diagnosis, prognosis and monitoring. We have also established paper-based assays for the rapid detection of various diseases, such as Dengue, Zika, hepatitis and sexually transmitted diseases. In addition, these inexpensive test kits can be used for food pathogen detection and meat speciation.